Genome-wide association studies [ESP74]

Course highlights

EC points

0.7

Start date

20-08-2018

End date

24-08-2018

Course days

Monday to Friday (5 mornings)

Faculty

Prof. Cornelia van Duijn, Dr. Fernando Rivadeneira

Course fee

€ 470

Location

Erasmus MC, Rotterdam NL

Level

Intermediate

Prerequisites

Basic understanding of genetic epidemiology (as covered by ESP43), the principles of linkage disequilibrium and the HapMap & 1000 Genomes project (as covered by ESP57) is advised.

Disciplines

  • Genetic Epidemiology

Application

Go to the ESP website

Detailed information about this course:

Description

Faculty: Prof. Cornelia van Duijn, Ir. PhD & Fernando Rivadeneira, MD PhD


Genome-wide association studies (GWAS) constitute a powerful approach to investigate the genetic basis of multifactorial disorders. In the last decade, GWAS have yielded spectacular successes in the discovery of genes involved in complex traits and disorders (e.g. body height, BMI, cardiovascular disease, cancer and neurological disorders). This was made possible by the advent of high-throughput genotyping technology and the knowledge on genome structure and organization derived from the HapMap and 1000 Genomes Projects. Applying the GWAS approach has facilitated researchers to incorporate these analyses into large genetic, clinical and epidemiological studies.


This course aims to introduce epidemiologists, molecular biologists and clinicians into the basic principles of GWAS, addressing aspects of study design, data collection and analysis, extending to the interpretation and follow-up of results. The course consists of lectures providing a conceptual framework on crucial aspects of quality control, imputation of missing genotypes, statistical tools, methods to detect and correct for stratification, meta-analysis and genomic annotation of GWAS signals; accompanied by instructive hands-on computer exercises on the principles of analysis of quantitative traits and disease outcomes using software packages that are available in the public domain.


The course format will allow interactive break-out discussion sessions on theoretical and practical aspects of running GWAS, together with expert-advice procurement on diverse components of collaborative research within networks and consortia.

Objectives

After completing the course, participants will be able to understand the principles of GWAS, perform a basic genome-wide association analysis, interpret results and integrate them in a genomic context by means of web-based bioinformatics resources.

Assessment

Attendance


Reduction on fees

PLEASE NOTE THIS DOES NOT APPLY TO THE RESEARCH MASTERS (120 ECTS)

50% reduction on our fees for participating institutes of NIHES

This 50% reduction is offered to participants formally appointed at the departments or sections participating in NIHES.

University Medical Center Rotterdam/Erasmus University Rotterdam:

  • Department of Epidemiology
  • Department of Public Health
  • Department of Psychiatry, Section of Medical Psychology and Psychotherapy
  • Department of Child and Adolescent Psychiatry/Psychology
  • Department of Medical Informatics
  • Department of General Practice
  • Erasmus School of Health Policy & Management
  • Generation R

50% reduction on our fees for NIHES affiliated partners

This 50% reduction is offered to participants formally appointed at the following NIHES affiliated partners:

University Medical Center Rotterdam/Erasmus University Rotterdam, departments of:

  • Dermatology
  • General Paediatrics
  • Plastic and Reconstructive Surgery
  • Rehabilitation Medicine

Institute of Medical Education Research Rotterdam (iMERR)

Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital

  • Department of Cancer Epidemiology

25% reduction on our fees for partner institutes of NIHES

For participants formally appointed at the following departments, institutes:

  • Departments of Erasmus MC (except the departments mentioned above)
  • Addiction Research Institute (IVO)
  • Integraal Kankercentrum Zuid (IKZ)
  • Pallas Health Research and Consultancy
  • Municipal Health Service Amsterdam (GGD Amsterdam)
  • Municipal Health Service Rotterdam (GGD Rotterdam)
  • Havenpolikliniek
  • Admiraal De Ruyter Ziekenhuis

25% reduction for all (international) PhD students
Please state your tutor’s name and email address on the application form (remarks field).

25% reduction on our course fees (maximum 3 EC points per academic year) for all NIHES alumni
Please state that you are a NIHES alumnus/alumna and the academic year you graduated (remarks field).