Family-based Genetic Analysis [GE05]

Course highlights

EC points




Course days

Monday to Friday


Prof. Heather Cordell, PhD , Prof. Peter Holmans, PhD

Course fee

€ 870


Erasmus MC, Rotterdam NL




Basic understanding of genetic epidemiology (level ESP29) and statistics (regression analysis and maximum likelihood estimation); familiarity with PC-compatible computers is required.


  • Genetic Epidemiology


How to apply

Detailed information about this course:


The course focuses on theoretical background and practical issues in the genetic analysis of complex traits. It considers two main gene-finding approaches: model-free linkage studies, and pedigree-based association analyses. It also addresses the analysis of qualitative outcomes - such as diseases - and quantitative (or continuous) traits.

As well as maximum-likelihood estimation and Haseman-Elston methods for model-free linkage analysis, we will also cover issues such as extreme sampling, the inclusion of covariates, and the generalization of methods based on sibling pairs to other pedigree structures.

Family-based association studies will be explored in the context of candidate genes and whole-genome association analysis. Various methods will be considered, including Transmission Disequilibrium-like tests, total tests that use between-family and withinfamily variation, and testing for maternal genotypeand parent-of-origin effects.


To familiarize participants with the theory of family-based studies, and also with genome-wide genetic analysis using open-source programs such as Merlin, R/GenABEL and PLINK.

Participant profile

Epidemiologists, geneticists, biostatisticians, investigators/physicians involved in clinical and pharmacological research. Experience in working with the Linux command line interface, e.g. at the level of the "Linux for Scientists" course (SC09).


Attendance, Assignment(s)

Reduction on fees


50% reduction on our fees for participating institutes of NIHES

This 50% reduction is offered to participants formally appointed at the departments or sections participating in NIHES.

University Medical Center Rotterdam/Erasmus University Rotterdam:

  • Department of Epidemiology
  • Department of Public Health
  • Department of Psychiatry, Section of Medical Psychology and Psychotherapy
  • Department of Child and Adolescent Psychiatry/Psychology
  • Department of Medical Informatics
  • Department of General Practice
  • Erasmus School of Health Policy & Management
  • Generation R

50% reduction on our fees for NIHES affiliated partners

This 50% reduction is offered to participants formally appointed at the following NIHES affiliated partners:

University Medical Center Rotterdam/Erasmus University Rotterdam, departments of:

  • Dermatology
  • General Paediatrics
  • Plastic and Reconstructive Surgery
  • Rehabilitation Medicine

Institute of Medical Education Research Rotterdam (iMERR)

Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital

  • Department of Cancer Epidemiology

25% reduction on our fees for partner institutes of NIHES

For participants formally appointed at the following departments, institutes:

  • Departments of Erasmus MC (except the departments mentioned above)
  • Addiction Research Institute (IVO)
  • Integraal Kankercentrum Zuid (IKZ)
  • Pallas Health Research and Consultancy
  • Municipal Health Service Amsterdam (GGD Amsterdam)
  • Municipal Health Service Rotterdam (GGD Rotterdam)
  • Havenpolikliniek
  • Admiraal De Ruyter Ziekenhuis

25% reduction for all (international) PhD students
Please state your supervisor/promotor’s name and email address on the application form (remarks field).

25% reduction on our course fees (maximum 3 EC points per academic year) for all NIHES alumni
Please state that you are a NIHES alumnus/alumna and the academic year you graduated (remarks field). Please note that the reduction on fees for alumni does not apply to the Erasmus Summer Programme.