Mendelian Randomisation [GE10]

Course highlights

EC points

0.9

Start date

29-03-2021

End date

31-03-2021

Course days

Monday to Wednesday

Faculty

Jeremy Labrecque, Carolina Borges, Katerina Trajanoska, and Fernando Rivadeneira

Course fee

€ 610

Location

Erasmus MC, Rotterdam NL

Level

Intermediate

Prerequisites

Understanding of genetic epidemiology and Statistics (elementary probability, and regression analysis)

Disciplines

  • Genetic Epidemiology

Application

How to apply

Detailed information about this course:

Description

With the advent of a very large number of genetic databases and resources, opportunities to conduct Mendelian randomization(MR) studies are quickly increasing. The MR approach proposes using genetic variants as instrumental variables to test or estimate the potential causal effect of a (non-genetic) risk factor on a disease or health-related outcome. When the assumptions are met, the MR approach can overcome the limitations of associations drawn from observational epidemiology and help prioritizing potential targets for pharmaceutical and public health interventions. This 3-day course aims to provide all the tools necessary first to understand the basic principles of causal inference underlying MR and second to perform an MR study; covering both simple and complex statistical methods for causal inference within one- and two- sample Mendelian randomisation frameworks. During the first day, basic principles of causal inference and mediation analysis will be covered. On the second day, students will apply the concepts learned on day 1 within a Mendelian randomisation framework; including methods to assess instrumental variable assumptions and working on hands-on practical sessions employing online tools like MR-base, but also using specific R-libraries. During day 3, examples of published MR studies will be presented followed by discussion of the topics and a short Q&A session. In addition, students will be able to run specific hands-on analyses with diverse summary level datasets. While theoretical background is provided on all topics, this is by definition a "hands-on" practical course, meaning you will spend most of the day performing MR analyses." Starting this year, the GE10 course will be given on a yearly basis.


Faculty: Jeremy Labrecque, Caroline Bonilla, Katerina Trajanoska and Fernando Rivadeneira

Objectives

  • Gain insight into disentangling the concepts of causation and association;
  • Learn aspects of design, execution and interpretation of MR studies;
  • Get familiar with hands-on applications (used for 1-sample and 2-sample MR) commonly used across MR/GWAS consortia.

Participant profile

Epidemiologists, geneticists, biostatisticians, investigators/physicians involved in clinical and pharmacological research.

Assessment

Assignment(s)


Reduction on fees

PLEASE NOTE THIS DOES NOT APPLY TO THE RESEARCH MASTERS (120 EC points)

50% reduction on our fees for participating institutes of NIHES

This 50% reduction is offered to participants formally appointed at the departments or sections participating in NIHES.

University Medical Center Rotterdam/Erasmus University Rotterdam:

  • Department of Epidemiology
  • Department of Public Health
  • Department of Psychiatry, Section of Medical Psychology and Psychotherapy
  • Department of Child and Adolescent Psychiatry/Psychology
  • Department of Medical Informatics
  • Department of General Practice
  • Erasmus School of Health Policy & Management
  • Generation R

50% reduction on our fees for NIHES affiliated partners

This 50% reduction is offered to participants formally appointed at the following NIHES affiliated partners:

University Medical Center Rotterdam/Erasmus University Rotterdam, departments of:

  • Dermatology
  • General Paediatrics
  • Plastic and Reconstructive Surgery
  • Rehabilitation Medicine

UMIT, Department of Public Health, Health Services Research and Health Technology Assessment.

25% reduction on our fees for Erasmus MC employees

For participants formally appointed at all departments of Erasmus MC (except the departments mentioned above).

25% reduction for all (international) PhD students
Please upload proof of enrollment as a PhD student in the application form and state the name of your tutor on the application form (remarks field).

25% reduction on our course fees (maximum 3 EC points per academic year) for all NIHES alumni
Please state that you are a NIHES alumnus/alumna and the academic year you graduated (remarks field). Please note that the reduction on fees for alumni does not apply to the Erasmus Summer Programme.