Advanced Decision Modeling [EL006]

Course highlights

EC points


Start date


End date


Course days

Weekdays (full days)


Jeremy Goldhaber-Fiebert, PhD

Course fee

€ 1250


Erasmus MC, Rotterdam NL




  • Advanced Topics in Medical Decision Making (EL004) or an equivalent advanced course in decision modeling (e.g. Harvard T.H. Chan School of Public Health RDS288 or RDS285)
  • Using R for Decision Modeling, Simulation, and Health Technology Assessment (EL005) or an equivalent particularly for those students planning to implement their project in R.


  • Clinical Epidemiology


How to apply

Detailed information about this course:


This week-long, project-based course aims to provide students with an understanding of advanced methods used in decision-analytic modeling and cost-effectiveness analyses. These include topics like the latest methods for calibration and validation, quantifying uncertainty, and consideration of heterogeneity of patient benefits and equity issues. The course combines lectures and readings to give theoretical foundation and perspectives with in depth project work and presentations to give practical concrete understanding in a way that furthers students’ specific research goals.

Course Structure (note: the online version of the course may differ somewhat):
Each day will begin with a lecture by Professor Goldhaber-Fiebert on an advanced methods topic. After the lecture, lab sessions will commence with students working on their projects as Professor Goldhaber-Fiebert circulates through the room and students assist each other in a collaborative environment. Most days Professor Goldhaber-Fiebert will also give an afternoon lecture. In addition, at the end of days 2, 3, and 4, Professor Goldhaber-Fiebert will give an additional, shorter, informal lecture (i.e., "a chalk talk") on a methods topic tailored to specific issues that are arising within students’ projects. Additionally, throughout the week, Professor Goldhaber-Fiebert will have one-on-one meetings with students about their projects.


  • Understand how empirical data can be used to indirectly estimate parameters and their uncertainty for decision analytic simulation models (calibration);
  • Be able to differentiate model calibration and model validation and to determine which situations it is appropriate to use each;
  • Understand the importance of correlations in the uncertainty distributions of model parameters for probabilistic sensitivity analyses (PSAs) and
  • Be able to identify methods to capture correlations in uncertainty for use in PSAs;
  • Understand how patient heterogeneity and behavioral responses can alter the results of cost-effectiveness analyses;
  • Be able to design models that capture patient heterogeneity and behavior;
  • Be able to describe Markov Decision Processes and other operations research techniques and to identify features of decision problems that make require these techniques;
  • Be able to describe key features and properties of compartmental dynamic transmission models for infectious diseases (i.e., SIR models) and how results of cost-effectiveness analyses of infectious disease control may depend on the types of models used;
  • Understand the use of Value of Information analyses in relation to standard cost-effectiveness analyses;
  • Be able to conduct an Expected Value of Perfect Information analysis;
  • Be able to design and implement a model based cost-effectiveness analysis that appropriately incorporates advanced decision modeling techniques.


Assignment(s), Attendance

Reduction on fees


No fees are charged for participation of Erasmus MC PhD candidates

Please note that in case of cancellation or no show, the cancellation policy applies based on the full course fee.

50% reduction on our fees for participating institutes of NIHES

This 50% reduction is offered to participants formally appointed at the departments or sections participating in NIHES.

University Medical Center Rotterdam/Erasmus University Rotterdam:

  • Department of Epidemiology
  • Department of Public Health
  • Department of Psychiatry, Section of Medical Psychology and Psychotherapy
  • Department of Child and Adolescent Psychiatry/Psychology
  • Department of Medical Informatics
  • Department of General Practice
  • Erasmus School of Health Policy & Management
  • Generation R

50% reduction on our fees for NIHES affiliated partners

This 50% reduction is offered to participants formally appointed at the following NIHES affiliated partners:

University Medical Center Rotterdam/Erasmus University Rotterdam, departments of:

  • Dermatology
  • General Paediatrics
  • Plastic and Reconstructive Surgery
  • Rehabilitation Medicine

UMIT, Department of Public Health, Health Services Research and Health Technology Assessment.

25% reduction on our fees for Erasmus MC employees

For participants formally appointed at all departments of Erasmus MC (except the departments mentioned above and Erasmus MC PhD candidates).

25% reduction for all (international) PhD students without formal appointment at Erasmus MC

Upon receipt of your application you will receive a request to upload proof of enrollment as a PhD student.